6W53
Trypanosoma cruzi Malic Enzyme in complex with inhibitor (MEC070)
Summary for 6W53
| Entry DOI | 10.2210/pdb6w53/pdb |
| Descriptor | Malic enzyme, N-(2-chloro-5-{[4-(trifluoromethoxy)phenyl]sulfamoyl}phenyl)-3,5-difluorobenzamide, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ... (4 entities in total) |
| Functional Keywords | inhibitor, oxidoreductase, oxidoreductase-inhibitor complex, oxidoreductase/inhibitor |
| Biological source | Trypanosoma cruzi |
| Total number of polymer chains | 1 |
| Total formula weight | 62355.54 |
| Authors | Mercaldi, G.F.,Fagundes, M.,Faria, J.N.,Cordeiro, A.T. (deposition date: 2020-03-12, release date: 2021-04-07, Last modification date: 2023-10-18) |
| Primary citation | Mercaldi, G.F.,Eufrasio, A.G.,Ranzani, A.T.,do Nascimento Faria, J.,Mota, S.G.R.,Fagundes, M.,Bruder, M.,Cordeiro, A.T. Trypanosoma cruzi Malic Enzyme Is the Target for Sulfonamide Hits from the GSK Chagas Box. Acs Infect Dis., 7:2455-2471, 2021 Cited by PubMed: 34279922DOI: 10.1021/acsinfecdis.1c00231 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
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