6W44

Crystal structure of HAO1 in complex with indazole acid inhibitor - compound 4

6W44 の概要

• エントリーDOI: 10.2210/pdb6w44/pdb
• 分子名称: Hydroxyacid oxidase 1, FLAVIN MONONUCLEOTIDE, 5-[methyl-[(2-propoxypyridin-3-yl)methyl]amino]-2~{H}-indazole-3-carboxylic acid, ... (4 entities in total)
• 機能のキーワード: inhibitor, complex, oxidoreductase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 41530.64

構造登録者

Ferguson, A.D. (登録日: 2020-03-10, 公開日: 2021-05-12, 最終更新日: 2023-10-18)

• 主引用文献: Lee, E.C.Y.,McRiner, A.J.,Georgiadis, K.E.,Liu, J.,Wang, Z.,Ferguson, A.D.,Levin, B.,von Rechenberg, M.,Hupp, C.D.,Monteiro, M.I.,Keefe, A.D.,Olszewski, A.,Eyermann, C.J.,Centrella, P.,Liu, Y.,Arora, S.,Cuozzo, J.W.,Zhang, Y.,Clark, M.A.,Huguet, C.,Kohlmann, A.; Discovery of Novel, Potent Inhibitors of Hydroxy Acid Oxidase 1 (HAO1) Using DNA-Encoded Chemical Library Screening.; J.Med.Chem., 64:6730-6744, 2021; PubMed: 33955740; DOI: 10.1021/acs.jmedchem.0c02271

実験手法

X-RAY DIFFRACTION (1.64 Å)