6W2N

Trypanosoma cruzi Malic Enzyme in complex with inhibitor (MEC009)

Summary for 6W2N

• Entry DOI: 10.2210/pdb6w2n/pdb
• Related: 6w29
• Descriptor: Malic enzyme, 3,5-bis(fluoranyl)-~{N}-[3-[(2-fluoranyl-4-methoxy-phenyl)sulfamoyl]phenyl]benzamide, CITRIC ACID, ... (5 entities in total)
• Functional Keywords: inhibitor, isomerase, oxidoreductase, oxidoreductase-inhibitor complex, oxidoreductase/inhibitor
• Biological source: Trypanosoma cruzi (strain CL Brener)
• Total number of polymer chains: 1
• Total formula weight: 62477.24

Authors

Mercaldi, G.F.,Fagundes, M.,Faria, J.N.,Cordeiro, A.T. (deposition date: 2020-03-06, release date: 2021-03-10, Last modification date: 2023-10-18)

• Primary citation: Mercaldi, G.F.,Eufrasio, A.G.,Ranzani, A.T.,do Nascimento Faria, J.,Mota, S.G.R.,Fagundes, M.,Bruder, M.,Cordeiro, A.T.; Trypanosoma cruzi Malic Enzyme Is the Target for Sulfonamide Hits from the GSK Chagas Box.; Acs Infect Dis., 7:2455-2471, 2021; PubMed: 34279922; DOI: 10.1021/acsinfecdis.1c00231

Experimental method

X-RAY DIFFRACTION (1.88 Å)