6VYA
Crystal structure of NotF in complex with brevianamide F and DMSPP
Summary for 6VYA
Entry DOI | 10.2210/pdb6vya/pdb |
Descriptor | Deoxybrevianamide E synthase notF, (3S,8aS)-3-(1H-indol-3-ylmethyl)hexahydropyrrolo[1,2-a]pyrazine-1,4-dione, DIMETHYLALLYL S-THIOLODIPHOSPHATE (3 entities in total) |
Functional Keywords | fungal indole prenyltransferase, transferase |
Biological source | Aspergillus sp. |
Total number of polymer chains | 24 |
Total formula weight | 1305064.66 |
Authors | Dan, Q.,Smith, J.L. (deposition date: 2020-02-25, release date: 2021-02-03, Last modification date: 2023-10-25) |
Primary citation | Kelly, S.P.,Shende, V.V.,Flynn, A.R.,Dan, Q.,Ye, Y.,Smith, J.L.,Tsukamoto, S.,Sigman, M.S.,Sherman, D.H. Data Science-Driven Analysis of Substrate-Permissive Diketopiperazine Reverse Prenyltransferase NotF: Applications in Protein Engineering and Cascade Biocatalytic Synthesis of (-)-Eurotiumin A. J.Am.Chem.Soc., 144:19326-19336, 2022 Cited by PubMed: 36223664DOI: 10.1021/jacs.2c06631 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3 Å) |
Structure validation
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