6VYA

Crystal structure of NotF in complex with brevianamide F and DMSPP

6VYA の概要

• エントリーDOI: 10.2210/pdb6vya/pdb
• 分子名称: Deoxybrevianamide E synthase notF, (3S,8aS)-3-(1H-indol-3-ylmethyl)hexahydropyrrolo[1,2-a]pyrazine-1,4-dione, DIMETHYLALLYL S-THIOLODIPHOSPHATE (3 entities in total)
• 機能のキーワード: fungal indole prenyltransferase, transferase
• 由来する生物種: Aspergillus sp.
• タンパク質・核酸の鎖数: 24
• 化学式量合計: 1305064.66

構造登録者

Dan, Q.,Smith, J.L. (登録日: 2020-02-25, 公開日: 2021-02-03, 最終更新日: 2023-10-25)

• 主引用文献: Kelly, S.P.,Shende, V.V.,Flynn, A.R.,Dan, Q.,Ye, Y.,Smith, J.L.,Tsukamoto, S.,Sigman, M.S.,Sherman, D.H.; Data Science-Driven Analysis of Substrate-Permissive Diketopiperazine Reverse Prenyltransferase NotF: Applications in Protein Engineering and Cascade Biocatalytic Synthesis of (-)-Eurotiumin A.; J.Am.Chem.Soc., 144:19326-19336, 2022; PubMed: 36223664; DOI: 10.1021/jacs.2c06631

実験手法

X-RAY DIFFRACTION (3 Å)