6VXG

Structure of the C-terminal Domain of RAGE and Its Inhibitor

6VXG の概要

• エントリーDOI: 10.2210/pdb6vxg/pdb
• 関連するPDBエントリー: 2LMB
• NMR情報: BMRB: 30726
• 分子名称: Advanced glycosylation end product-specific receptor, N-(4-{7-cyano-4-[(morpholin-4-yl)methyl]quinolin-2-yl}phenyl)acetamide (2 entities in total)
• 機能のキーワード: inhibitor, complex, diabetes, receptor for advanced glycated end products, inflammation, signaling protein, signaling protein-inhibitor complex, signaling protein/inhibitor
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 5421.69

構造登録者

Ramirez, L.,Shekhtman, A. (登録日: 2020-02-21, 公開日: 2021-02-24, 最終更新日: 2024-05-15)

• 主引用文献: Manigrasso, M.B.,Rabbani, P.,Egana-Gorrono, L.,Quadri, N.,Frye, L.,Zhou, B.,Reverdatto, S.,Ramirez, L.S.,Dansereau, S.,Pan, J.,Li, H.,D'Agati, V.D.,Ramasamy, R.,DeVita, R.J.,Shekhtman, A.,Schmidt, A.M.; Small-molecule antagonism of the interaction of the RAGE cytoplasmic domain with DIAPH1 reduces diabetic complications in mice.; Sci Transl Med, 13:eabf7084-eabf7084, 2021; PubMed: 34818060; DOI: 10.1126/scitranslmed.abf7084

実験手法

SOLUTION NMR