6VUB
Crystal structure of BRD4 bromodomain 1 with N-methylpyrrolidin-2-one (NMP) derivative 5 (1-methyl-4-phenylpyrrolidin-2-one)
Summary for 6VUB
| Entry DOI | 10.2210/pdb6vub/pdb |
| Descriptor | Bromodomain-containing protein 4, (4R)-1-methyl-4-phenylpyrrolidin-2-one (3 entities in total) |
| Functional Keywords | brd4 bd1, bromodomain, nmp, protein binding |
| Biological source | Homo sapiens (Human) |
| Total number of polymer chains | 1 |
| Total formula weight | 15143.41 |
| Authors | Ilyichova, O.V.,Scanlon, M.J.,Thompson, P.E. (deposition date: 2020-02-14, release date: 2020-02-26, Last modification date: 2023-10-11) |
| Primary citation | Hilton-Proctor, J.P.,Ilyichova, O.,Zheng, Z.,Jennings, I.G.,Johnstone, R.W.,Shortt, J.,Mountford, S.J.,Scanlon, M.J.,Thompson, P.E. Substituted 1-methyl-4-phenylpyrrolidin-2-ones - Fragment-based design of N-methylpyrrolidone-derived bromodomain inhibitors. Eur.J.Med.Chem., 191:112120-112120, 2020 Cited by PubMed: 32120339DOI: 10.1016/j.ejmech.2020.112120 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.5 Å) |
Structure validation
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