6VNU

X-ray Crystal Structure of Ruthenocenyl-7-Aminocephalosporanic Acid Covalent Acyl-Enzyme Complex with CTX-M-14 E166A Beta-Lactamase

6VNU の概要

• エントリーDOI: 10.2210/pdb6vnu/pdb
• 分子名称: Beta-lactamase, ruthenocene, [(1,2,3,4,5-eta)-1-(4-{[carboxy(4-carboxy-5-methylidene-5,6-dihydro-2H-1,3-thiazin-2-yl)methyl]amino}-4-oxobutanoyl)cyclopentadienyl][(1,2,3,4,5-eta)-cyclopentadienyl]ruthenium, ... (5 entities in total)
• 機能のキーワード: organometallic, ctx-m-14, hydrolase
• 由来する生物種: Escherichia coli
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 57725.95

構造登録者

Lewandowski, E.M.,Jacobs, L.M.C.,Chen, Y. (登録日: 2020-01-29, 公開日: 2020-04-01, 最終更新日: 2023-10-11)

• 主引用文献: Lewandowski, E.M.,Szczupak, L.,Kowalczyk, A.,Mendoza, G.,Arruebo, M.,Jacobs, L.M.C.,Staczek, P.,Chen, Y.,Kowalski, K.; Metallocenyl 7-ACA Conjugates: Antibacterial Activity Studies and Atomic-Resolution X-ray Crystal Structure with CTX-M beta-Lactamase.; Chembiochem, 21:2187-2195, 2020; PubMed: 32182393; DOI: 10.1002/cbic.202000054

実験手法

X-RAY DIFFRACTION (1.47 Å)