6VNR
Crystal Structure of Danio rerio Histone Deacetylase 6 Catalytic Domain 2 (CD2) Complexed with Bishydroxamic Acid Inhibitor
Summary for 6VNR
Entry DOI | 10.2210/pdb6vnr/pdb |
Descriptor | Hdac6 protein, ZINC ION, POTASSIUM ION, ... (6 entities in total) |
Functional Keywords | histone deacetylase, metallohydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Danio rerio (Zebrafish) |
Total number of polymer chains | 2 |
Total formula weight | 81632.95 |
Authors | Osko, J.D.,Porter, N.J.,Christianson, D.W. (deposition date: 2020-01-29, release date: 2020-05-13, Last modification date: 2023-10-11) |
Primary citation | Morgen, M.,Steimbach, R.R.,Geraldy, M.,Hellweg, L.,Sehr, P.,Ridinger, J.,Witt, O.,Oehme, I.,Herbst-Gervasoni, C.J.,Osko, J.D.,Porter, N.J.,Christianson, D.W.,Gunkel, N.,Miller, A.K. Design and Synthesis of Dihydroxamic Acids as HDAC6/8/10 Inhibitors. Chemmedchem, 15:1163-1174, 2020 Cited by PubMed: 32348628DOI: 10.1002/cmdc.202000149 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.94301319072 Å) |
Structure validation
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