6VNR

Crystal Structure of Danio rerio Histone Deacetylase 6 Catalytic Domain 2 (CD2) Complexed with Bishydroxamic Acid Inhibitor

Summary for 6VNR

Entry DOI	10.2210/pdb6vnr/pdb
Descriptor	Hdac6 protein, ZINC ION, POTASSIUM ION, ... (6 entities in total)
Functional Keywords	histone deacetylase, metallohydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Danio rerio (Zebrafish)
Total number of polymer chains	2
Total formula weight	81632.95
Authors	Osko, J.D.,Porter, N.J.,Christianson, D.W. (deposition date: 2020-01-29, release date: 2020-05-13, Last modification date: 2023-10-11)
Primary citation	Morgen, M.,Steimbach, R.R.,Geraldy, M.,Hellweg, L.,Sehr, P.,Ridinger, J.,Witt, O.,Oehme, I.,Herbst-Gervasoni, C.J.,Osko, J.D.,Porter, N.J.,Christianson, D.W.,Gunkel, N.,Miller, A.K. Design and Synthesis of Dihydroxamic Acids as HDAC6/8/10 Inhibitors. Chemmedchem, 15:1163-1174, 2020 Cited by PubMed: 32348628 DOI: 10.1002/cmdc.202000149 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.94301319072 Å)

Structure validation