6VN2

USP7 IN COMPLEX WITH LIGAND COMPOUND 18

6VN2 の概要

• エントリーDOI: 10.2210/pdb6vn2/pdb
• 分子名称: Ubiquitin carboxyl-terminal hydrolase 7, 1-({7-[(2R)-5-chloro-2-(piperazine-1-carbonyl)-2,3-dihydro-1-benzofuran-7-yl]thieno[3,2-b]pyridin-2-yl}methyl)-1H-pyrrole-2,5-dione, ACETATE ION, ... (4 entities in total)
• 機能のキーワード: usp7, dub, deubiquitinase, hydrolase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 82032.51

構造登録者

Leger, P.R.,Wustrow, D.J.,Hu, D.X.,Krapp, S.,Maskos, K.,Blaesse, M. (登録日: 2020-01-29, 公開日: 2020-04-29, 最終更新日: 2020-06-17)

• 主引用文献: Leger, P.R.,Hu, D.X.,Biannic, B.,Bui, M.,Han, X.,Karbarz, E.,Maung, J.,Okano, A.,Osipov, M.,Shibuya, G.M.,Young, K.,Higgs, C.,Abraham, B.,Bradford, D.,Cho, C.,Colas, C.,Jacobson, S.,Ohol, Y.M.,Pookot, D.,Rana, P.,Sanchez, J.,Shah, N.,Sun, M.,Wong, S.,Brockstedt, D.G.,Kassner, P.D.,Schwarz, J.B.,Wustrow, D.J.; Discovery of Potent, Selective, and Orally Bioavailable Inhibitors of USP7 with In Vivo Antitumor Activity.; J.Med.Chem., 63:5398-5420, 2020; PubMed: 32302140; DOI: 10.1021/acs.jmedchem.0c00245

実験手法

X-RAY DIFFRACTION (2.93 Å)