6VJJ

Crystal Structure of wild-type KRAS4b (GMPPNP-bound) in complex with RAS-binding domain (RBD) of RAF1/CRAF

Summary for 6VJJ

Entry DOI	10.2210/pdb6vjj/pdb
Descriptor	GTPase KRas, RAF proto-oncogene serine/threonine-protein kinase, MAGNESIUM ION, ... (8 entities in total)
Functional Keywords	kras, ras, k-ras, kras4b, raf1, craf, rbd, ras-binding domain, oncoprotein
Biological source	Homo sapiens (Human) More
Total number of polymer chains	2
Total formula weight	29330.63
Authors	Tran, T.H.,Dharmaiah, S.,Simanshu, D.K. (deposition date: 2020-01-16, release date: 2020-11-25, Last modification date: 2023-10-11)
Primary citation	Tran, T.H.,Chan, A.H.,Young, L.C.,Bindu, L.,Neale, C.,Messing, S.,Dharmaiah, S.,Taylor, T.,Denson, J.P.,Esposito, D.,Nissley, D.V.,Stephen, A.G.,McCormick, F.,Simanshu, D.K. KRAS interaction with RAF1 RAS-binding domain and cysteine-rich domain provides insights into RAS-mediated RAF activation. Nat Commun, 12:1176-1176, 2021 Cited by PubMed: 33608534 DOI: 10.1038/s41467-021-21422-x PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.4 Å)

Structure validation