6VJJ

Crystal Structure of wild-type KRAS4b (GMPPNP-bound) in complex with RAS-binding domain (RBD) of RAF1/CRAF

6VJJ の概要

• エントリーDOI: 10.2210/pdb6vjj/pdb
• 分子名称: GTPase KRas, RAF proto-oncogene serine/threonine-protein kinase, MAGNESIUM ION, ... (8 entities in total)
• 機能のキーワード: kras, ras, k-ras, kras4b, raf1, craf, rbd, ras-binding domain, oncoprotein
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 29330.63

構造登録者

Tran, T.H.,Dharmaiah, S.,Simanshu, D.K. (登録日: 2020-01-16, 公開日: 2020-11-25, 最終更新日: 2023-10-11)

• 主引用文献: Tran, T.H.,Chan, A.H.,Young, L.C.,Bindu, L.,Neale, C.,Messing, S.,Dharmaiah, S.,Taylor, T.,Denson, J.P.,Esposito, D.,Nissley, D.V.,Stephen, A.G.,McCormick, F.,Simanshu, D.K.; KRAS interaction with RAF1 RAS-binding domain and cysteine-rich domain provides insights into RAS-mediated RAF activation.; Nat Commun, 12:1176-1176, 2021; PubMed: 33608534; DOI: 10.1038/s41467-021-21422-x

実験手法

X-RAY DIFFRACTION (1.4 Å)