6VCT

Mucor circinelloides FKBP12 protein bound with APX879 in C2221 space group

6VCT の概要

• エントリーDOI: 10.2210/pdb6vct/pdb
• 分子名称: Peptidylprolyl isomerase, N'-[(3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-5,19-dihydroxy-3-{(1E)-1-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]prop-1-en-2-yl}-14,16-dimethoxy-4,10,12,18-tetramethyl-1,20,21-trioxo-8-(prop-2-en-1-yl)-1,3,4,5,6,8,11,12,13,14,15,16,17,18,19,20,21,23,24,25,26,26a-docosahydro-7H-15,19-epoxypyrido[2,1-c][1,4]oxazacyclotricosin-7-ylidene]acetohydrazide (3 entities in total)
• 機能のキーワード: fk506-binding protein 1a, fkbp12, fk506, isomerase
• 由来する生物種: Mucor circinelloides
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 12955.75

構造登録者

Gobeil, S.,Spicer, L. (登録日: 2019-12-23, 公開日: 2020-12-16, 最終更新日: 2023-10-11)

• 主引用文献: Gobeil, S.M.,Bobay, B.G.,Juvvadi, P.R.,Cole, D.C.,Heitman, J.,Steinbach, W.J.,Venters, R.A.,Spicer, L.D.; Leveraging Fungal and Human Calcineurin-Inhibitor Structures, Biophysical Data, and Dynamics To Design Selective and Nonimmunosuppressive FK506 Analogs.; Mbio, 12:e0300021-e0300021, 2021; PubMed: 34809463; DOI: 10.1128/mBio.03000-21

実験手法

X-RAY DIFFRACTION (1.94 Å)