6VBD

Crystal structure of transpeptidase domain of PBP2 from Neisseria gonorrhoeae cephalosporin-resistant strain H041 acylated by ceftriaxone

Summary for 6VBD

• Entry DOI: 10.2210/pdb6vbd/pdb
• Descriptor: Probable peptidoglycan D,D-transpeptidase PenA, CEFOTAXIME, C3' cleaved, open, bound form, GLYCEROL, ... (4 entities in total)
• Functional Keywords: penicillin-binding protein, acylation, antibiotic resistance, hydrolase, hydrolase-antibiotic complex, hydrolase/antibiotic
• Biological source: Neisseria gonorrhoeae
• Total number of polymer chains: 1
• Total formula weight: 35851.02

Authors

Singh, A.,Davies, C. (deposition date: 2019-12-18, release date: 2020-04-15, Last modification date: 2024-11-06)

• Primary citation: Singh, A.,Turner, J.,Tomberg, J.,Fedarovich, A.,Unemo, M.,Nicholas, R.A.,Davies, C.; Mutations in Neisseria gonorrhoeae penicillin-binding protein 2 associated with extended-spectrum cephalosporin resistance create an energetic barrier against acylation via restriction of protein dynamics; J.Biol.Chem., 2020

Experimental method

X-RAY DIFFRACTION (1.8 Å)