6V8Y

Structure of a Sodium Potassium ion Channel

6V8Y の概要

• エントリーDOI: 10.2210/pdb6v8y/pdb
• 分子名称: Potassium channel protein, (4S)-2-METHYL-2,4-PENTANEDIOL, POTASSIUM ION, ... (5 entities in total)
• 機能のキーワード: ion channel, membrane protein
• 由来する生物種: Bacillus cereus
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 22521.74

構造登録者

Roy, R.,Weiss, K.L.,Coates, L. (登録日: 2019-12-12, 公開日: 2021-04-14, 最終更新日: 2023-10-11)

主引用文献

Roy, R.N.,Hendriks, K.,Kopec, W.,Abdolvand, S.,Weiss, K.L.,de Groot, B.L.,Lange, A.,Sun, H.,Coates, L.
Structural plasticity of the selectivity filter in a nonselective ion channel.
Iucrj, 8:421-430, 2021

PubMed Abstract: The sodium potassium ion channel (NaK) is a nonselective ion channel that conducts both sodium and potassium across the cellular membrane. A new crystallographic structure of NaK reveals conformational differences in the residues that make up the selectivity filter between the four subunits that form the ion channel and the inner helix of the ion channel. The crystallographic structure also identifies a side-entry, ion-conduction pathway for Na permeation that is unique to NaK. NMR studies and molecular dynamics simulations confirmed the dynamical nature of the top part of the selectivity filter and the inner helix in NaK as also observed in the crystal structure. Taken together, these results indicate that the structural plasticity of the selectivity filter combined with the dynamics of the inner helix of NaK are vital for the efficient conduction of different ions through the non-selective ion channel of NaK.

PubMed: 33953928
DOI: 10.1107/S205225252100213X

実験手法

X-RAY DIFFRACTION (1.53 Å)