6V6P

Crystal structure of CTX-M-14 E166A/D240G beta-lactamase

Summary for 6V6P

• Entry DOI: 10.2210/pdb6v6p/pdb
• Related: 6V5E
• Descriptor: Beta-lactamase, SULFATE ION, DI(HYDROXYETHYL)ETHER, ... (4 entities in total)
• Functional Keywords: drug resistance, protein evolution, conformational change, enzyme kinetics, enzyme catalysis, protein stability, protein-drug interaction, hydrolase
• Biological source: Escherichia coli
• Total number of polymer chains: 1
• Total formula weight: 28086.66

Authors

Brown, C.A.,Hu, L.,Sankaran, B.,Prasad, B.V.V.,Palzkill, T.G. (deposition date: 2019-12-05, release date: 2020-04-22, Last modification date: 2023-10-11)

• Primary citation: Brown, C.A.,Hu, L.,Sun, Z.,Patel, M.P.,Singh, S.,Porter, J.R.,Sankaran, B.,Prasad, B.V.V.,Bowman, G.R.,Palzkill, T.; Antagonism between substitutions in beta-lactamase explains a path not taken in the evolution of bacterial drug resistance.; J.Biol.Chem., 295:7376-7390, 2020; PubMed: 32299911; DOI: 10.1074/jbc.RA119.012489

Experimental method

X-RAY DIFFRACTION (1.55 Å)