6V6L

Co-structure of human glycogen synthase kinase beta with 1-(6-((2-((6-amino-5-nitropyridin-2-yl)amino)ethyl)amino)-2-(2,4-dichlorophenyl)pyridin-3-yl)-4-methylpiperazin-2-one

Summary for 6V6L

• Entry DOI: 10.2210/pdb6v6l/pdb
• Descriptor: Glycogen synthase kinase-3 beta, 1-(6-((2-((6-amino-5-nitropyridin-2-yl)amino)ethyl)amino)-2-(2,4-dichlorophenyl)pyridin-3-yl)-4-methylpiperazin-2-one, PHOSPHATE ION, ... (4 entities in total)
• Functional Keywords: kinase, transferase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 47507.56

Authors

Bussiere, D.E.,Fang, E.,Shu, W. (deposition date: 2019-12-05, release date: 2020-01-15, Last modification date: 2023-11-15)

• Primary citation: Ramurthy, S.,Pfister, K.B.,Boyce, R.S.,Brown, S.P.,Costales, A.Q.,Desai, M.C.,Fang, E.,Levine, B.H.,Ng, S.C.,Nuss, J.M.,Ring, D.B.,Shafer, C.M.,Shu, W.,Subramanian, S.,Wagman, A.S.,Wang, H.,Bussiere, D.E.; Discovery and optimization of novel pyridines as highly potent and selective glycogen synthase kinase 3 inhibitors.; Bioorg.Med.Chem.Lett., 30:126930-126930, 2020; PubMed: 31926786; DOI: 10.1016/j.bmcl.2019.126930

Experimental method

X-RAY DIFFRACTION (2.19 Å)