6UYM
Structure of Hepatitis C Virus Envelope Glycoprotein E2mc3-v6 redesigned core from genotype 1a bound to broadly neutralizing antibody AR3C
Summary for 6UYM
Entry DOI | 10.2210/pdb6uym/pdb |
Descriptor | Envelope glycoprotein E2, Fab AR3C heavy chain, Fab AR3C light chain, ... (5 entities in total) |
Functional Keywords | hcv, e2 core, vaccine design, self-assembly nanoparticle, broadly neutralizing antibodies, bnabs, immune system, viral protein-immune system complex, viral protein/immune system |
Biological source | Hepatitis C virus (isolate H) More |
Total number of polymer chains | 6 |
Total formula weight | 136316.88 |
Authors | Tzarum, N.,Wilson, I.A.,Zhu, J. (deposition date: 2019-11-13, release date: 2020-04-22, Last modification date: 2023-10-11) |
Primary citation | He, L.,Tzarum, N.,Lin, X.,Shapero, B.,Sou, C.,Mann, C.J.,Stano, A.,Zhang, L.,Nagy, K.,Giang, E.,Law, M.,Wilson, I.A.,Zhu, J. Proof of concept for rational design of hepatitis C virus E2 core nanoparticle vaccines. Sci Adv, 6:eaaz6225-eaaz6225, 2020 Cited by PubMed: 32494617DOI: 10.1126/sciadv.aaz6225 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.848 Å) |
Structure validation
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