6UYD

Structure of Hepatitis C Virus Envelope Glycoprotein E2mc3-v1 redesigned core from genotype 1a bound to broadly neutralizing antibody AR3C

Summary for 6UYD

Entry DOI	10.2210/pdb6uyd/pdb
Descriptor	Envelope glycoprotein E2, Fab AR3C heavy chain, Fab AR3C light chain, ... (6 entities in total)
Functional Keywords	hcv, e2 core, vaccine design, self-assembly nanoparticle, broadly neutralizing antibodies, bnabs, viral protein-immune system complex, viral protein/immune system
Biological source	Hepatitis C virus (isolate H) More
Total number of polymer chains	6
Total formula weight	136523.91
Authors	Tzarum, N.,Wilson, I.A.,Zhu, J. (deposition date: 2019-11-13, release date: 2020-04-22, Last modification date: 2023-10-11)
Primary citation	He, L.,Tzarum, N.,Lin, X.,Shapero, B.,Sou, C.,Mann, C.J.,Stano, A.,Zhang, L.,Nagy, K.,Giang, E.,Law, M.,Wilson, I.A.,Zhu, J. Proof of concept for rational design of hepatitis C virus E2 core nanoparticle vaccines. Sci Adv, 6:eaaz6225-eaaz6225, 2020 Cited by PubMed: 32494617 DOI: 10.1126/sciadv.aaz6225 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.897 Å)

Structure validation