6UX8

Structure of monobody 33 MLKL N-terminal domain complex

Summary for 6UX8

• Entry DOI: 10.2210/pdb6ux8/pdb
• Descriptor: Mixed lineage kinase domain-like protein, Monobody, ZINC ION, ... (4 entities in total)
• Functional Keywords: protein interactions, cell death, ripk3, programmed necrosis, protein engineering, transferase
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 2
• Total formula weight: 28977.14

Authors

Birkinshaw, R.W.,Petrie, E.J.,Murphy, J.M. (deposition date: 2019-11-07, release date: 2020-04-01, Last modification date: 2023-10-11)

• Primary citation: Petrie, E.J.,Birkinshaw, R.W.,Koide, A.,Denbaum, E.,Hildebrand, J.M.,Garnish, S.E.,Davies, K.A.,Sandow, J.J.,Samson, A.L.,Gavin, X.,Fitzgibbon, C.,Young, S.N.,Hennessy, P.J.,Smith, P.P.C.,Webb, A.I.,Czabotar, P.E.,Koide, S.,Murphy, J.M.; Identification of MLKL membrane translocation as a checkpoint in necroptotic cell death using Monobodies.; Proc.Natl.Acad.Sci.USA, 117:8468-8475, 2020; PubMed: 32234780; DOI: 10.1073/pnas.1919960117

Experimental method