6UW2

Clotrimazole bound complex of Acanthamoeba castellanii CYP51

Summary for 6UW2

• Entry DOI: 10.2210/pdb6uw2/pdb
• Descriptor: Obtusifoliol 14alphademethylase, PROTOPORPHYRIN IX CONTAINING FE, 1-[(2-CHLOROPHENYL)(DIPHENYL)METHYL]-1H-IMIDAZOLE, ... (5 entities in total)
• Functional Keywords: cyp51, ergosterol biosynthesis, acanthamoeba, 14- alpha-demethylase, oxidoreductase, clotrimazole
• Biological source: Acanthamoeba castellanii str. Neff
• Total number of polymer chains: 6
• Total formula weight: 320629.10

Authors

Sharma, V.,Podust, L.M. (deposition date: 2019-11-04, release date: 2020-10-21, Last modification date: 2023-10-11)

• Primary citation: Sharma, V.,Shing, B.,Hernandez-Alvarez, L.,Debnath, A.,Podust, L.M.; Domain-Swap Dimerization of Acanthamoeba castellanii CYP51 and a Unique Mechanism of Inactivation by Isavuconazole.; Mol.Pharmacol., 98:770-780, 2020; PubMed: 33008918; DOI: 10.1124/molpharm.120.000092

Experimental method

X-RAY DIFFRACTION (2.92 Å)