6UW2

Clotrimazole bound complex of Acanthamoeba castellanii CYP51

6UW2 の概要

• エントリーDOI: 10.2210/pdb6uw2/pdb
• 分子名称: Obtusifoliol 14alphademethylase, PROTOPORPHYRIN IX CONTAINING FE, 1-[(2-CHLOROPHENYL)(DIPHENYL)METHYL]-1H-IMIDAZOLE, ... (5 entities in total)
• 機能のキーワード: cyp51, ergosterol biosynthesis, acanthamoeba, 14- alpha-demethylase, oxidoreductase, clotrimazole
• 由来する生物種: Acanthamoeba castellanii str. Neff
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 320629.10

構造登録者

Sharma, V.,Podust, L.M. (登録日: 2019-11-04, 公開日: 2020-10-21, 最終更新日: 2023-10-11)

• 主引用文献: Sharma, V.,Shing, B.,Hernandez-Alvarez, L.,Debnath, A.,Podust, L.M.; Domain-Swap Dimerization of Acanthamoeba castellanii CYP51 and a Unique Mechanism of Inactivation by Isavuconazole.; Mol.Pharmacol., 98:770-780, 2020; PubMed: 33008918; DOI: 10.1124/molpharm.120.000092

実験手法

X-RAY DIFFRACTION (2.92 Å)