6UVM

Cocrystal of BRD4(D1) with a methyl carbamate thiazepane inhibitor

6UVM の概要

• エントリーDOI: 10.2210/pdb6uvm/pdb
• 分子名称: Bromodomain-containing protein 4, 1-[(7S)-7-(thiophen-2-yl)-6,7-dihydro-1,4-thiazepin-4(5H)-yl]ethan-1-one, 1,2-ETHANEDIOL, ... (4 entities in total)
• 機能のキーワード: brd4(d1), inhibitor, gene regulation-inhibitor complex, gene regulation/inhibitor
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 15400.80

構造登録者

Johnson, J.A.,Pomerantz, W.C.K. (登録日: 2019-11-03, 公開日: 2020-01-01, 最終更新日: 2023-10-11)

• 主引用文献: Johnson, J.A.,Nicolaou, C.A.,Kirberger, S.E.,Pandey, A.K.,Hu, H.,Pomerantz, W.C.K.; Evaluating the Advantages of Using 3D-Enriched Fragments for Targeting BET Bromodomains.; Acs Med.Chem.Lett., 10:1648-1654, 2019; PubMed: 31857841; DOI: 10.1021/acsmedchemlett.9b00414

実験手法

X-RAY DIFFRACTION (1.51 Å)