6UVK

OXA-48 bound by inhibitor CDD-97

Summary for 6UVK

Entry DOI	10.2210/pdb6uvk/pdb
Descriptor	Beta-lactamase, 1-{4-[4-(2-ethoxyphenyl)piperazin-1-yl]-1,3,5-triazin-2-yl}piperidine-4-carboxylic acid, 1,2-ETHANEDIOL, ... (6 entities in total)
Functional Keywords	inhibitor, beta-lactamase, oxa-48, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Klebsiella pneumoniae
Total number of polymer chains	4
Total formula weight	115152.74
Authors	Taylor, D.M.,Hu, L.,Prasad, B.V.V.,Sankaran, B.,Palzkill, T.G. (deposition date: 2019-11-02, release date: 2020-05-06, Last modification date: 2023-11-15)
Primary citation	Taylor, D.M.,Anglin, J.,Park, S.,Ucisik, M.N.,Faver, J.C.,Simmons, N.,Jin, Z.,Palaniappan, M.,Nyshadham, P.,Li, F.,Campbell, J.,Hu, L.,Sankaran, B.,Prasad, B.V.V.,Huang, H.,Matzuk, M.M.,Palzkill, T. Identifying Oxacillinase-48 Carbapenemase Inhibitors Using DNA-Encoded Chemical Libraries. Acs Infect Dis., 6:1214-1227, 2020 Cited by PubMed: 32182432 DOI: 10.1021/acsinfecdis.0c00015 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation