6UVA
CryoEM Structure of the active Adrenomedullin 2 receptor G protein complex with adrenomedullin 2 peptide
Summary for 6UVA
Entry DOI | 10.2210/pdb6uva/pdb |
EMDB information | 20906 |
Descriptor | Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... (7 entities in total) |
Functional Keywords | gpcr, adrenomedullin receptor complex, membrane protein |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 7 |
Total formula weight | 185513.33 |
Authors | Belousoff, M.J.,Liang, Y.L.,Sexton, P.,Danev, R. (deposition date: 2019-11-01, release date: 2020-04-01, Last modification date: 2020-04-29) |
Primary citation | Liang, Y.L.,Belousoff, M.J.,Fletcher, M.M.,Zhang, X.,Khoshouei, M.,Deganutti, G.,Koole, C.,Furness, S.G.B.,Miller, L.J.,Hay, D.L.,Christopoulos, A.,Reynolds, C.A.,Danev, R.,Wootten, D.,Sexton, P.M. Structure and Dynamics of Adrenomedullin Receptors AM1and AM2Reveal Key Mechanisms in the Control of Receptor Phenotype by Receptor Activity-Modifying Proteins. Acs Pharmacol Transl Sci, 3:263-284, 2020 Cited by PubMed: 32296767DOI: 10.1021/acsptsci.9b00080 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (2.3 Å) |
Structure validation
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