6UVA

CryoEM Structure of the active Adrenomedullin 2 receptor G protein complex with adrenomedullin 2 peptide

6UVA の概要

• エントリーDOI: 10.2210/pdb6uva/pdb
• EMDBエントリー: 20906
• 分子名称: Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... (7 entities in total)
• 機能のキーワード: gpcr, adrenomedullin receptor complex, membrane protein
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 7
• 化学式量合計: 185513.33

構造登録者

Belousoff, M.J.,Liang, Y.L.,Sexton, P.,Danev, R. (登録日: 2019-11-01, 公開日: 2020-04-01, 最終更新日: 2020-04-29)

• 主引用文献: Liang, Y.L.,Belousoff, M.J.,Fletcher, M.M.,Zhang, X.,Khoshouei, M.,Deganutti, G.,Koole, C.,Furness, S.G.B.,Miller, L.J.,Hay, D.L.,Christopoulos, A.,Reynolds, C.A.,Danev, R.,Wootten, D.,Sexton, P.M.; Structure and Dynamics of Adrenomedullin Receptors AM1and AM2Reveal Key Mechanisms in the Control of Receptor Phenotype by Receptor Activity-Modifying Proteins.; Acs Pharmacol Transl Sci, 3:263-284, 2020; PubMed: 32296767; DOI: 10.1021/acsptsci.9b00080

実験手法

ELECTRON MICROSCOPY (2.3 Å)