6UJ4

Discovery of fragment-inspired heterocyclic benzenesulfonmides as inhibitors of the WDR5-MYC interaction

6UJ4 の概要

• エントリーDOI: 10.2210/pdb6uj4/pdb
• 分子名称: WD repeat domain 5, 5-bromo-3-chloro-N-(1-cyclopentyl-2-methyl-1H-imidazol-4-yl)-2-hydroxybenzene-1-sulfonamide (3 entities in total)
• 機能のキーワード: wdr5, myc, structure-based design, fragment screening, transcription
• 由来する生物種: Homo sapiens
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 67853.51

構造登録者

Zhao, B. (登録日: 2019-10-02, 公開日: 2020-04-15, 最終更新日: 2023-10-11)

• 主引用文献: Chacon Simon, S.,Wang, F.,Thomas, L.R.,Phan, J.,Zhao, B.,Olejniczak, E.T.,Macdonald, J.D.,Shaw, J.G.,Schlund, C.,Payne, W.,Creighton, J.,Stauffer, S.R.,Waterson, A.G.,Tansey, W.P.,Fesik, S.W.; Discovery of WD Repeat-Containing Protein 5 (WDR5)-MYC Inhibitors Using Fragment-Based Methods and Structure-Based Design.; J.Med.Chem., 63:4315-4333, 2020; PubMed: 32223236; DOI: 10.1021/acs.jmedchem.0c00224

実験手法

X-RAY DIFFRACTION (1.53 Å)