6UH4
B. theta Bile Salt Hydrolase with covalent inhibitor
Summary for 6UH4
Entry DOI | 10.2210/pdb6uh4/pdb |
Related | 6UFY |
Descriptor | Choloylglycine hydrolase, (5R,6R)-6-[(1S,2R,4aS,4bS,7R,8aS,10R,10aS)-7,10-dihydroxy-1,2,4b-trimethyltetradecahydrophenanthren-2-yl]-5-methylheptan-2-one (2 entities in total) |
Functional Keywords | bile salt hydrolase b. theta, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Bacteroides thetaiotaomicron |
Total number of polymer chains | 4 |
Total formula weight | 152241.37 |
Authors | Seegar, T.C.M. (deposition date: 2019-09-26, release date: 2020-02-19, Last modification date: 2023-10-11) |
Primary citation | Adhikari, A.A.,Seegar, T.C.M.,Ficarro, S.B.,McCurry, M.D.,Ramachandran, D.,Yao, L.,Chaudhari, S.N.,Ndousse-Fetter, S.,Banks, A.S.,Marto, J.A.,Blacklow, S.C.,Devlin, A.S. Development of a covalent inhibitor of gut bacterial bile salt hydrolases. Nat.Chem.Biol., 16:318-326, 2020 Cited by PubMed: 32042200DOI: 10.1038/s41589-020-0467-3 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.51 Å) |
Structure validation
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