6UFR

Structure of recombinantly assembled E46K alpha-synuclein fibrils

Summary for 6UFR

Entry DOI	10.2210/pdb6ufr/pdb
EMDB information	20759
Descriptor	Alpha-synuclein (2 entities in total)
Functional Keywords	alpha-synuclein, amyloid, fibril, e46k, hereditary mutations, parkinson's disease, lewy body dementia, protein fibril
Biological source	Homo sapiens (Human)
Total number of polymer chains	10
Total formula weight	144761.75
Authors	Eisenberg, D.S.,Boyer, D.R.,Sawaya, M.R.,Li, B.,Jiang, L. (deposition date: 2019-09-24, release date: 2020-02-19, Last modification date: 2024-03-20)
Primary citation	Boyer, D.R.,Li, B.,Sun, C.,Fan, W.,Zhou, K.,Hughes, M.P.,Sawaya, M.R.,Jiang, L.,Eisenberg, D.S. The alpha-synuclein hereditary mutation E46K unlocks a more stable, pathogenic fibril structure. Proc.Natl.Acad.Sci.USA, 117:3592-3602, 2020 Cited by PubMed: 32015135 DOI: 10.1073/pnas.1917914117 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (2.5 Å)

Structure validation