6UFD

Carbonic anhydrase 2 with inhibitor (2Z)-3-oxo-N-(4-sulfamoylphenyl)-2-[(thiophen-2-yl)methylidene]butanamide (11g/D7)

6UFD の概要

• エントリーDOI: 10.2210/pdb6ufd/pdb
• 分子名称: Carbonic anhydrase 2, ZINC ION, GLYCEROL, ... (6 entities in total)
• 機能のキーワード: carbonic anhydrase, inhibitor, complex, lyase-lyase inhibitor complex, lyase/lyase inhibitor
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 30016.62

構造登録者

Peat, T.S. (登録日: 2019-09-24, 公開日: 2020-08-05, 最終更新日: 2023-10-11)

• 主引用文献: Fares, M.,Eldehna, W.M.,Bua, S.,Lanzi, C.,Lucarini, L.,Masini, E.,Peat, T.S.,Abdel-Aziz, H.A.,Nocentini, A.,Keller, P.A.,Supuran, C.T.; Discovery of Potent Dual-Tailed Benzenesulfonamide Inhibitors of Human Carbonic Anhydrases Implicated in Glaucoma and in Vivo Profiling of Their Intraocular Pressure-Lowering Action.; J.Med.Chem., 63:3317-3326, 2020; PubMed: 32031797; DOI: 10.1021/acs.jmedchem.9b02090

実験手法

X-RAY DIFFRACTION (1.48 Å)