6UFC
Carbonic anhydrase 2 with inhibitor (2Z)-2-[(4-methoxyphenyl)methylidene]-3-oxo-N-(4-sulfamoylphenyl)butanamide (11d/D4)
Summary for 6UFC
Entry DOI | 10.2210/pdb6ufc/pdb |
Descriptor | Carbonic anhydrase 2, ZINC ION, (2Z)-2-[(4-methoxyphenyl)methylidene]-3-oxo-N-(4-sulfamoylphenyl)butanamide, ... (6 entities in total) |
Functional Keywords | carbonic anhydrase, inhibitor, complex, lyase-lyase inhibitor complex, lyase/lyase inhibitor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 29843.97 |
Authors | Peat, T.S. (deposition date: 2019-09-24, release date: 2020-08-05, Last modification date: 2023-10-11) |
Primary citation | Fares, M.,Eldehna, W.M.,Bua, S.,Lanzi, C.,Lucarini, L.,Masini, E.,Peat, T.S.,Abdel-Aziz, H.A.,Nocentini, A.,Keller, P.A.,Supuran, C.T. Discovery of Potent Dual-Tailed Benzenesulfonamide Inhibitors of Human Carbonic Anhydrases Implicated in Glaucoma and in Vivo Profiling of Their Intraocular Pressure-Lowering Action. J.Med.Chem., 63:3317-3326, 2020 Cited by PubMed: 32031797DOI: 10.1021/acs.jmedchem.9b02090 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.325 Å) |
Structure validation
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