6UDL

Structure of Human Cytochrome P450 1A1 with Duocarmycin Prodrug (S) ICT-2700

Summary for 6UDL

• Entry DOI: 10.2210/pdb6udl/pdb
• Descriptor: Cytochrome P450 1A1, PROTOPORPHYRIN IX CONTAINING FE, [(1S)-1-(chloromethyl)-1,6-dihydropyrrolo[3,2-e]indol-3(2H)-yl](5-methoxy-1H-indol-2-yl)methanone, ... (4 entities in total)
• Functional Keywords: cyp1a1, p450, oxidoreductase, duocarmycin
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 4
• Total formula weight: 227002.25

Authors

Bart, A.G.,Scott, E.E. (deposition date: 2019-09-19, release date: 2020-09-23, Last modification date: 2023-10-11)

• Primary citation: Bart, A.G.,Morais, G.,Vangala, V.R.,Loadman, P.M.,Pors, K.,Scott, E.E.; Cytochrome P450 binding and bioactivation of tumor-targeted duocarmycin agents; Drug Metab.Dispos., 2021

Experimental method

X-RAY DIFFRACTION (2.85 Å)