6UDA

Cryo-EM structure of CH235UCA bound to Man5-enriched CH505.N279K.G458Y.SOSIP.664

Summary for 6UDA

• Entry DOI: 10.2210/pdb6uda/pdb
• EMDB information: 20735
• Descriptor: CH505.N279K.G458Y.SOSIP.664 gp120, CH235 UCA heavy chain Fab, CH505.N279K.G458Y.SOSIP.664 gp41, ... (6 entities in total)
• Functional Keywords: ch235 lineage, ch505 virus, vaccine design, cryo-em, viral protein, viral protein-immune system complex, viral protein/immune system
• Biological source: Human immunodeficiency virus 1; More
• Total number of polymer chains: 12
• Total formula weight: 378539.12

Authors

Henderson, R.,Acharya, P. (deposition date: 2019-09-19, release date: 2019-10-02, Last modification date: 2020-07-29)

• Primary citation: LaBranche, C.C.,Henderson, R.,Hsu, A.,Behrens, S.,Chen, X.,Zhou, T.,Wiehe, K.,Saunders, K.O.,Alam, S.M.,Bonsignori, M.,Borgnia, M.J.,Sattentau, Q.J.,Eaton, A.,Greene, K.,Gao, H.,Liao, H.X.,Williams, W.B.,Peacock, J.,Tang, H.,Perez, L.G.,Edwards, R.J.,Kepler, T.B.,Korber, B.T.,Kwong, P.D.,Mascola, J.R.,Acharya, P.,Haynes, B.F.,Montefiori, D.C.; Neutralization-guided design of HIV-1 envelope trimers with high affinity for the unmutated common ancester of CH235 lineage CD4bs broadly neutralizing antibodies.; Plos Pathog., 15:e1008026-e1008026, 2019; PubMed: 31527908; DOI: 10.1371/journal.ppat.1008026

Experimental method

ELECTRON MICROSCOPY (4.2 Å)