6UCF

N123-VRC34_pI4 HIV neutralizing antibody in complex with HIV fusion peptide residue 512-519

Summary for 6UCF

• Entry DOI: 10.2210/pdb6ucf/pdb
• Descriptor: N123-VRC34_pI4 light chain, N123-VRC34_pI4 heavy chain, HIV fusion peptide, ... (4 entities in total)
• Functional Keywords: hiv, neutralizing, antibody, fusion peptide, immune system-viral protein complex, antiviral protein, immune system/viral protein
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 3
• Total formula weight: 48530.15

Authors

Xu, K.,Kwong, P.D. (deposition date: 2019-09-16, release date: 2020-03-18, Last modification date: 2020-04-22)

• Primary citation: Shen, C.H.,DeKosky, B.J.,Guo, Y.,Xu, K.,Gu, Y.,Kilam, D.,Ko, S.H.,Kong, R.,Liu, K.,Louder, M.K.,Ou, L.,Zhang, B.,Chao, C.W.,Corcoran, M.M.,Feng, E.,Huang, J.,Normandin, E.,O'Dell, S.,Ransier, A.,Rawi, R.,Sastry, M.,Schmidt, S.D.,Wang, S.,Wang, Y.,Chuang, G.Y.,Doria-Rose, N.A.,Lin, B.,Zhou, T.,Boritz, E.A.,Connors, M.,Douek, D.C.,Karlsson Hedestam, G.B.,Sheng, Z.,Shapiro, L.,Mascola, J.R.,Kwong, P.D.; VRC34-Antibody Lineage Development Reveals How a Required Rare Mutation Shapes the Maturation of a Broad HIV-Neutralizing Lineage.; Cell Host Microbe, 27:531-, 2020; PubMed: 32130953; DOI: 10.1016/j.chom.2020.01.027

Experimental method

X-RAY DIFFRACTION (1.29 Å)