6U99

Hsp90a NTD covalently bound to sulfonyl fluoride probe 1 at K58

6U99 の概要

• エントリーDOI: 10.2210/pdb6u99/pdb
• 分子名称: Heat shock protein HSP 90-alpha, 3-{[(3-{6-amino-8-[(6-iodo-2H-1,3-benzodioxol-5-yl)sulfanyl]-9H-purin-9-yl}propyl)amino]methyl}benzene-1-sulfinic acid (3 entities in total)
• 機能のキーワード: inhibitor, lysine-targeted inhibitor, chaperone, chaperone-inhibitor complex, chaperone/inhibitor
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 29304.46

構造登録者

Cuesta, A.,Wan, X.,Taunton, J. (登録日: 2019-09-06, 公開日: 2020-02-19, 最終更新日: 2023-10-11)

• 主引用文献: Cuesta, A.,Wan, X.,Burlingame, A.L.,Taunton, J.; Ligand Conformational Bias Drives Enantioselective Modification of a Surface-Exposed Lysine on Hsp90.; J.Am.Chem.Soc., 142:3392-3400, 2020; PubMed: 32009391; DOI: 10.1021/jacs.9b09684

実験手法

X-RAY DIFFRACTION (1.6 Å)