6U37

Structure of VX-phosphonylated hAChE in complex with oxime reactivator RS194B

6U37 の概要

• エントリーDOI: 10.2210/pdb6u37/pdb
• 分子名称: Acetylcholinesterase, O-ETHYLMETHYLPHOSPHONIC ACID ESTER GROUP, (2E)-N-[2-(azepan-1-yl)ethyl]-2-(hydroxyimino)acetamide, ... (6 entities in total)
• 機能のキーワード: oxime reactivator complex, vx-phosphonylated conjugate, hydrolase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 121805.05

構造登録者

Kovalevsky, A.,Gerlits, O.,Radic, Z. (登録日: 2019-08-21, 公開日: 2020-02-12, 最終更新日: 2023-10-11)

• 主引用文献: Gorecki, L.,Gerlits, O.,Kong, X.,Cheng, X.,Blumenthal, D.K.,Taylor, P.,Ballatore, C.,Kovalevsky, A.,Radic, Z.; Rational design, synthesis, and evaluation of uncharged, "smart" bis-oxime antidotes of organophosphate-inhibited human acetylcholinesterase.; J.Biol.Chem., 295:4079-4092, 2020; PubMed: 32019865; DOI: 10.1074/jbc.RA119.012400

実験手法

X-RAY DIFFRACTION (2.25 Å)