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6U2X

Structure of ALDH7A1 mutant E399G complexed with NAD

Summary for 6U2X
Entry DOI10.2210/pdb6u2x/pdb
DescriptorAlpha-aminoadipic semialdehyde dehydrogenase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE (3 entities in total)
Functional Keywordsaldehyde dehydrogenase, nad, oxidoreductase, lysine catabolism
Biological sourceHomo sapiens (Human)
Total number of polymer chains8
Total formula weight449693.84
Authors
Tanner, J.J.,Korasick, D.A.,Laciak, A.R. (deposition date: 2019-08-20, release date: 2019-11-06, Last modification date: 2023-10-11)
Primary citationLaciak, A.R.,Korasick, D.A.,Gates, K.S.,Tanner, J.J.
Structural analysis of pathogenic mutations targeting Glu427 of ALDH7A1, the hot spot residue of pyridoxine-dependent epilepsy.
J. Inherit. Metab. Dis., 43:635-644, 2020
Cited by
PubMed: 31652343
DOI: 10.1002/jimd.12184
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.15 Å)
Structure validation

221051

数据于2024-06-12公开中

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