6TZI
ADC-7 in complex with boronic acid transition state inhibitor PFC_001
Summary for 6TZI
| Entry DOI | 10.2210/pdb6tzi/pdb |
| Descriptor | Beta-lactamase, phosphonooxy-[[4-[[2,2,2-tris(fluoranyl)ethylsulfonylamino]methyl]-1,2,3-triazol-1-yl]methyl]borinic acid (3 entities in total) |
| Functional Keywords | inhibitor, beta-lactamase, batsi, adc-7, hydrolase |
| Biological source | Acinetobacter baumannii |
| Total number of polymer chains | 4 |
| Total formula weight | 164762.06 |
| Authors | Fish, E.R.,Powers, R.A.,Wallar, B.J. (deposition date: 2019-08-12, release date: 2020-06-24, Last modification date: 2023-10-11) |
| Primary citation | Caselli, E.,Fini, F.,Introvigne, M.L.,Stucchi, M.,Taracila, M.A.,Fish, E.R.,Smolen, K.A.,Rather, P.N.,Powers, R.A.,Wallar, B.J.,Bonomo, R.A.,Prati, F. 1,2,3-Triazolylmethaneboronate: A Structure Activity Relationship Study of a Class of beta-Lactamase Inhibitors againstAcinetobacter baumanniiCephalosporinase. Acs Infect Dis., 6:1965-1975, 2020 Cited by PubMed: 32502340DOI: 10.1021/acsinfecdis.0c00254 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.744 Å) |
Structure validation
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