6TXW
V30G Transthyretin structure in complex with Tolcalpone
Summary for 6TXW
| Entry DOI | 10.2210/pdb6txw/pdb |
| Descriptor | Transthyretin, Tolcapone (3 entities in total) |
| Functional Keywords | drug repositioning, tolcapone, leptomeningeal amyloidosis, transport protein |
| Biological source | Homo sapiens (Human) |
| Total number of polymer chains | 2 |
| Total formula weight | 25868.76 |
| Authors | Varejao, N.,Reverter, D.,Pinheiro, F.,Pallares, I.,Ventura, S. (deposition date: 2020-01-14, release date: 2020-05-13, Last modification date: 2024-01-24) |
| Primary citation | Pinheiro, F.,Varejao, N.,Esperante, S.,Santos, J.,Velazquez-Campoy, A.,Reverter, D.,Pallares, I.,Ventura, S. Tolcapone, a potent aggregation inhibitor for the treatment of familial leptomeningeal amyloidosis. Febs J., 288:310-324, 2021 Cited by PubMed: 32324953DOI: 10.1111/febs.15339 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.153 Å) |
Structure validation
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