6TWP

Binding domain of BoNT/A5

これはPDB形式変換不可エントリーです。

6TWP の概要

• エントリーDOI: 10.2210/pdb6twp/pdb
• 分子名称: Botulinum neurotoxin A5, CHLORIDE ION (3 entities in total)
• 機能のキーワード: binding domain, botulinum neurotoxin, toxin
• 由来する生物種: Clostridium botulinum
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 50757.88

構造登録者

Davies, J.R.,Acharya, K.R. (登録日: 2020-01-13, 公開日: 2020-07-22, 最終更新日: 2024-01-24)

主引用文献

Davies, J.R.,Britton, A.,Liu, S.M.,Acharya, K.R.
High-resolution crystal structures of the botulinum neurotoxin binding domains from subtypes A5 and A6.
Febs Open Bio, 10:1474-1481, 2020

PubMed Abstract: Clostridium botulinum neurotoxins (BoNTs) cause flaccid paralysis through inhibition of acetylcholine release from motor neurons; however, at tiny doses, this property is exploited for use as a therapeutic. Each member of the BoNT family of proteins consists of three distinct domains: a binding domain that targets neuronal cell membranes (H ), a translocation domain (H ) and a catalytic domain (LC). Here, we present high-resolution crystal structures of the binding domains of BoNT subtypes/A5 (H /A5) and/A6 (H /A6). These structures show that the core fold identified in other subtypes is maintained, but with subtle differences at the expected receptor-binding sites.

PubMed: 32654405
DOI: 10.1002/2211-5463.12931

実験手法

X-RAY DIFFRACTION (1.15 Å)