6TW3

HumRadA2 in complex with Naphthyl-HPA fragment-peptide chimera

6TW3 の概要

• エントリーDOI: 10.2210/pdb6tw3/pdb
• 分子名称: DNA repair and recombination protein RadA, PHOSPHATE ION, (2~{S})-1-[(2~{S})-2-[(3-azanylnaphthalen-2-yl)carbonylamino]-3-(1~{H}-imidazol-4-yl)propanoyl]-~{N}-[(2~{S})-1-azanyl-1-oxidanylidene-propan-2-yl]pyrrolidine-2-carboxamide, ... (4 entities in total)
• 機能のキーワード: rad51, recombinase, dna repair, dna binding protein
• 由来する生物種: Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 26183.63

構造登録者

Marsh, M.E.,Fischer, G.,Scott, D.E.,Coyne, A.G.,Skidmore, J.,Abell, C.,Hyvonen, M. (登録日: 2020-01-12, 公開日: 2021-01-27, 最終更新日: 2024-01-24)

• 主引用文献: Scott, D.E.,Francis-Newton, N.J.,Marsh, M.E.,Coyne, A.G.,Fischer, G.,Moschetti, T.,Bayly, A.R.,Sharpe, T.D.,Haas, K.T.,Barber, L.,Valenzano, C.R.,Srinivasan, R.,Huggins, D.J.,Lee, M.,Emery, A.,Hardwick, B.,Ehebauer, M.,Dagostin, C.,Esposito, A.,Pellegrini, L.,Perrior, T.,McKenzie, G.,Blundell, T.L.,Hyvonen, M.,Skidmore, J.,Venkitaraman, A.R.,Abell, C.; A small-molecule inhibitor of the BRCA2-RAD51 interaction modulates RAD51 assembly and potentiates DNA damage-induced cell death.; Cell Chem Biol, 28:835-, 2021; PubMed: 33662256; DOI: 10.1016/j.chembiol.2021.02.006

実験手法

X-RAY DIFFRACTION (1.352 Å)