6TT5

Crystal structure of DCLRE1C/Artemis

This is a non-PDB format compatible entry.

Summary for 6TT5

• Entry DOI: 10.2210/pdb6tt5/pdb
• Descriptor: Protein artemis, 1,2-ETHANEDIOL, ZINC ION, ... (5 entities in total)
• Functional Keywords: endonuclease, dna repair, v(d)j recombination, nhej recombination, hydrolase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 42334.99

Authors

Yosaatmadja, Y.,Goubin, S.,Newman, J.A.,Mukhopadhyay, S.M.M.,Dannerfjord, A.A.,Burgess-Brown, N.A.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.,Bountra, C.,Gileadi, O. (deposition date: 2019-12-23, release date: 2020-02-12, Last modification date: 2024-01-24)

• Primary citation: Yosaatmadja, Y.,Baddock, H.T.,Newman, J.A.,Bielinski, M.,Gavard, A.E.,Mukhopadhyay, S.M.M.,Dannerfjord, A.A.,Schofield, C.J.,McHugh, P.J.,Gileadi, O.; Structural and mechanistic insights into the Artemis endonuclease and strategies for its inhibition.; Nucleic Acids Res., 49:9310-9326, 2021; PubMed: 34387696; DOI: 10.1093/nar/gkab693

Experimental method

X-RAY DIFFRACTION (1.5 Å)