6TSG

Crystal structure of Peroxisome proliferator-activated receptor gamma (PPARG) in complex with TETRAC

Summary for 6TSG

Entry DOI	10.2210/pdb6tsg/pdb
Descriptor	Peroxisome proliferator-activated receptor gamma, 3,3',5,5'-TETRAIODOTHYROACETIC ACID (3 entities in total)
Functional Keywords	pparg, steroid hormone receptor, inhibitor, structural genomics, structural genomics consortium, sgc, dna binding protein
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	32415.62
Authors	Chaikuad, A.,Gellrich, L.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Merk, D.,Knapp, S.,Structural Genomics Consortium (SGC) (deposition date: 2019-12-20, release date: 2020-07-22, Last modification date: 2024-01-24)
Primary citation	Gellrich, L.,Heitel, P.,Heering, J.,Kilu, W.,Pollinger, J.,Goebel, T.,Kahnt, A.,Arifi, S.,Pogoda, W.,Paulke, A.,Steinhilber, D.,Proschak, E.,Wurglics, M.,Schubert-Zsilavecz, M.,Chaikuad, A.,Knapp, S.,Bischoff, I.,Furst, R.,Merk, D. l-Thyroxin and the Nonclassical Thyroid Hormone TETRAC Are Potent Activators of PPAR gamma. J.Med.Chem., 63:6727-6740, 2020 Cited by PubMed: 32356658 DOI: 10.1021/acs.jmedchem.9b02150 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.98 Å)

Structure validation