6TSG

Crystal structure of Peroxisome proliferator-activated receptor gamma (PPARG) in complex with TETRAC

6TSG の概要

• エントリーDOI: 10.2210/pdb6tsg/pdb
• 分子名称: Peroxisome proliferator-activated receptor gamma, 3,3',5,5'-TETRAIODOTHYROACETIC ACID (3 entities in total)
• 機能のキーワード: pparg, steroid hormone receptor, inhibitor, structural genomics, structural genomics consortium, sgc, dna binding protein
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 32415.62

構造登録者

Chaikuad, A.,Gellrich, L.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Merk, D.,Knapp, S.,Structural Genomics Consortium (SGC) (登録日: 2019-12-20, 公開日: 2020-07-22, 最終更新日: 2024-01-24)

• 主引用文献: Gellrich, L.,Heitel, P.,Heering, J.,Kilu, W.,Pollinger, J.,Goebel, T.,Kahnt, A.,Arifi, S.,Pogoda, W.,Paulke, A.,Steinhilber, D.,Proschak, E.,Wurglics, M.,Schubert-Zsilavecz, M.,Chaikuad, A.,Knapp, S.,Bischoff, I.,Furst, R.,Merk, D.; l-Thyroxin and the Nonclassical Thyroid Hormone TETRAC Are Potent Activators of PPAR gamma.; J.Med.Chem., 63:6727-6740, 2020; PubMed: 32356658; DOI: 10.1021/acs.jmedchem.9b02150

実験手法

X-RAY DIFFRACTION (2.98 Å)