6TSE

Crystal Structure of 1-methylindoline-2,3-dione covalently bound to the PH domain of Bruton's tyrosine kinase mutant R28C

6TSE の概要

• エントリーDOI: 10.2210/pdb6tse/pdb
• 分子名称: Tyrosine-protein kinase BTK, MAGNESIUM ION, 1-methylindole-2,3-dione, ... (5 entities in total)
• 機能のキーワード: btk, covalent fragments, surface entrophy reduction, crystal engineering, transferase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 40681.98

構造登録者

Brear, P.,Wagstaff, J.,Hyvonen, M. (登録日: 2019-12-20, 公開日: 2020-11-25, 最終更新日: 2024-01-24)

• 主引用文献: Brear, P.,Fischer, G.,May, M.,Pantelejevs, T.,Mathieu, R.,Rossmann, M.,Wagstaff, J.,Blaszczyk, B.,Hyvonen, M.; Crystal Structure of 1-methylindoline-2,3-dione covalently bound to the PH domain of Bruton's tyrosine kinase mutant R28C; To Be Published,

実験手法

X-RAY DIFFRACTION (1.41 Å)