6TSD

Crystal structure of human coxsackievirus A24v in complex with pentavalent inhibitor ME0752

これはPDB形式変換不可エントリーです。

6TSD の概要

• エントリーDOI: 10.2210/pdb6tsd/pdb
• 関連するPDBエントリー: 4Q4V 4Q4W 4Q4X 4Q4Y
• 分子名称: Capsid protein VP1, MAGNESIUM ION, Capsid protein VP2, ... (11 entities in total)
• 機能のキーワード: human coxsackievirus a24v, starfish-like inhibitor, pentavelent, virus
• 由来する生物種: Coxsackievirus A24; 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 99430.40

構造登録者

Zocher, G.,Stehle, T. (登録日: 2019-12-20, 公開日: 2021-07-07, 最終更新日: 2024-01-31)

主引用文献

Johansson, E.,Caraballo, R.,Mistry, N.,Zocher, G.,Qian, W.,Andersson, C.D.,Hurdiss, D.L.,Chandra, N.,Thompson, R.,Frangsmyr, L.,Stehle, T.,Arnberg, N.,Elofsson, M.
Pentavalent Sialic Acid Conjugates Block Coxsackievirus A24 Variant and Human Adenovirus Type 37-Viruses That Cause Highly Contagious Eye Infections.
Acs Chem.Biol., 15:2683-2691, 2020

PubMed Abstract: Coxsackievirus A24 variant (CVA24v) and human adenovirus 37 (HAdV-37) are leading causative agents of the severe and highly contagious ocular infections acute hemorrhagic conjunctivitis and epidemic keratoconjunctivitis, respectively. Currently, neither vaccines nor antiviral agents are available for treating these diseases, which affect millions of individuals worldwide. CVA24v and HAdV-37 utilize sialic acid as attachment receptors facilitating entry into host cells. Previously, we and others have shown that derivatives based on sialic acid are effective in preventing HAdV-37 binding and infection of cells. Here, we designed and synthesized novel pentavalent sialic acid conjugates and studied their inhibitory effect against CVA24v and HAdV-37 binding and infection of human corneal epithelial cells. The pentavalent conjugates are the first reported inhibitors of CVA24v infection and proved efficient in blocking HAdV-37 binding. Taken together, the pentavalent conjugates presented here form a basis for the development of general inhibitors of these highly contagious ocular pathogens.

PubMed: 32845119
DOI: 10.1021/acschembio.0c00446

実験手法

X-RAY DIFFRACTION (1.81 Å)