6TON

Crystal structure of human BCL6 BTB domain in complex with compound 25b

6TON の概要

• エントリーDOI: 10.2210/pdb6ton/pdb
• 分子名称: B-cell lymphoma 6 protein, ALA-TRP-VAL-ILE-PRO-ALA, 5-[[5-chloranyl-2-(2,2,6,6-tetramethylmorpholin-4-yl)pyrimidin-4-yl]amino]-1-methyl-3-(3-methyl-3-oxidanyl-butyl)benzimidazol-2-one, ... (5 entities in total)
• 機能のキーワード: cancer, lymphoma, inhibitor, degrader, transcription
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 15819.87

構造登録者

Rodrigues, M.J.,Le Bihan, Y.-V.,van Montfort, R.L.M. (登録日: 2019-12-11, 公開日: 2020-04-22, 最終更新日: 2024-01-24)

• 主引用文献: Bellenie, B.R.,Cheung, K.J.,Varela, A.,Pierrat, O.A.,Collie, G.W.,Box, G.M.,Bright, M.D.,Gowan, S.,Hayes, A.,Rodrigues, M.J.,Shetty, K.N.,Carter, M.,Davis, O.A.,Henley, A.T.,Innocenti, P.,Johnson, L.D.,Liu, M.,de Klerk, S.,Le Bihan, Y.V.,Lloyd, M.G.,McAndrew, P.C.,Shehu, E.,Talbot, R.,Woodward, H.L.,Burke, R.,Kirkin, V.,van Montfort, R.L.M.,Raynaud, F.I.,Rossanese, O.W.,Hoelder, S.; AchievingIn VivoTarget Depletion through the Discovery and Optimization of Benzimidazolone BCL6 Degraders.; J.Med.Chem., 63:4047-4068, 2020; PubMed: 32275432; DOI: 10.1021/acs.jmedchem.9b02076

実験手法

X-RAY DIFFRACTION (2.36 Å)