6TOK

Crystal structure of human BCL6 BTB domain in complex with compound 23d

Summary for 6TOK

• Entry DOI: 10.2210/pdb6tok/pdb
• Descriptor: B-cell lymphoma 6 protein, ALA-TRP-VAL-ILE-PRO-ALA, 5-[[5-chloranyl-2-(3,5-dimethylpyrazol-1-yl)pyrimidin-4-yl]amino]-1-methyl-3-(3-methyl-3-oxidanyl-butyl)benzimidazol-2-one, ... (6 entities in total)
• Functional Keywords: cancer, lymphoma, inhibitor, degrader, transcription
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 2
• Total formula weight: 16705.99

Authors

Rodrigues, M.J.,Le Bihan, Y.-V.,van Montfort, R.L.M. (deposition date: 2019-12-11, release date: 2020-04-22, Last modification date: 2024-01-24)

• Primary citation: Bellenie, B.R.,Cheung, K.J.,Varela, A.,Pierrat, O.A.,Collie, G.W.,Box, G.M.,Bright, M.D.,Gowan, S.,Hayes, A.,Rodrigues, M.J.,Shetty, K.N.,Carter, M.,Davis, O.A.,Henley, A.T.,Innocenti, P.,Johnson, L.D.,Liu, M.,de Klerk, S.,Le Bihan, Y.V.,Lloyd, M.G.,McAndrew, P.C.,Shehu, E.,Talbot, R.,Woodward, H.L.,Burke, R.,Kirkin, V.,van Montfort, R.L.M.,Raynaud, F.I.,Rossanese, O.W.,Hoelder, S.; AchievingIn VivoTarget Depletion through the Discovery and Optimization of Benzimidazolone BCL6 Degraders.; J.Med.Chem., 63:4047-4068, 2020; PubMed: 32275432; DOI: 10.1021/acs.jmedchem.9b02076

Experimental method

X-RAY DIFFRACTION (1.43 Å)