6TOJ

Crystal structure of human BCL6 BTB domain in complex with compound 17a

6TOJ の概要

• エントリーDOI: 10.2210/pdb6toj/pdb
• 分子名称: B-cell lymphoma 6 protein, 2-chloranyl-4-[[1-methyl-3-(3-methyl-3-oxidanyl-butyl)-2-oxidanylidene-benzimidazol-5-yl]amino]pyridine-3-carbonitrile, 1,2-ETHANEDIOL, ... (4 entities in total)
• 機能のキーワード: cancer, lymphoma, inhibitor, degrader, transcription
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 17133.07

構造登録者

Rodrigues, M.J.,Le Bihan, Y.-V.,van Montfort, R.L.M. (登録日: 2019-12-11, 公開日: 2020-04-22, 最終更新日: 2024-01-24)

• 主引用文献: Bellenie, B.R.,Cheung, K.J.,Varela, A.,Pierrat, O.A.,Collie, G.W.,Box, G.M.,Bright, M.D.,Gowan, S.,Hayes, A.,Rodrigues, M.J.,Shetty, K.N.,Carter, M.,Davis, O.A.,Henley, A.T.,Innocenti, P.,Johnson, L.D.,Liu, M.,de Klerk, S.,Le Bihan, Y.V.,Lloyd, M.G.,McAndrew, P.C.,Shehu, E.,Talbot, R.,Woodward, H.L.,Burke, R.,Kirkin, V.,van Montfort, R.L.M.,Raynaud, F.I.,Rossanese, O.W.,Hoelder, S.; AchievingIn VivoTarget Depletion through the Discovery and Optimization of Benzimidazolone BCL6 Degraders.; J.Med.Chem., 63:4047-4068, 2020; PubMed: 32275432; DOI: 10.1021/acs.jmedchem.9b02076

実験手法

X-RAY DIFFRACTION (1.85 Å)